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454 Life Sciences sequencing system plays role in landmark genotyping study
November 2009
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BASEL, Switzerland—A study published online in October in Nature Medicine reports that researchers at the Wisconsin National Primate Research Center have explored a new high-throughput method for decoding one of the most critical genomic regions for the immune system. In the study, researchers used ultra-deep sequencing with the Genome Sequencer FLX System from 454 Life Sciences, a Roche company, to perform rapid major histocompatibility complex (MHC) class I genotyping in macaques, a common model primate. The MHC is a gene-rich portion of the human and monkey genome that plays a critical role in the immune system. According to 454 Life Sciences, the study demonstrates that its sequencing system can dramatically improve upon traditional Sanger sequencing methods by enabling the discovery of new genotypes that had previously been missed.  

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