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High Throughput Screening NEWS
2019-05-13
  
Code: E051904
2019-03-26
  
Code: E03271901
2019-03-12
  
Code: E031907
BMG Labtech
 
VEGF was fluorescently labeled at a single site. This ligand was used with HEK293 expressing VEGF-receptor 2 (VEGFR2) fused to NanoLuc®. Interaction between ligand and receptor leads to BRET between luciferase and fluorophore. Both signals were acquired simultaneously with the PHERAstar®. This way, pKi of a VEGF-inhibitor and time-course of inhibition were measured.
 
Receptor tyrosine kinases (RTK) such as VEGF are transmembrane receptors that translate stimulation by growth factors to cell death or cell growth. Aberrant RTK-signaling is implicated in cancer, making it a therapeutic target.
 
2018-11-13
  
Code: E111829
2018-10-11
  
Code: E101806
2018-10-11
  
Code: E101821
2018-09-12
  
Code: E091829
BMG Labtech
 
YEATS domains are epigenetic regulators and readers of histone post-translational modifications. They bind to lysine when the ε-carbon is acylated. The YEATS-containing ENL is a major driver of several types of acute leukaemia and a rational drug target.
 
An AlphaScreen-based peptide binding assay was developed that reports on the interaction of modified histone 3 with the YEATS domains. Inhibitor screening was performed on a PHERAstar® and uncovered a potent small molecule inhibitor interfering with the YEATS domains of ENL and AF9.
 
2018-06-12
  
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2018-06-12
  
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2018-02-14
  
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2017-10-10
  
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2017-09-14
  
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2017-09-12
  
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2017-04-14
  
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2017-04-14
  
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2017-03-12
  
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2016-11-10
  
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2016-09-13
  
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2016-03-10
  
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2016-02-16
  
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2016-02-16
  
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2015-12-09
  
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2015-12-07
  
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2015-11-13
  
2015-09-09
  
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2015-04-09
  
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2015-02-23
  
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2015-02-10
  
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2014-10-13
  
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2014-09-10
  
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2014-08-12
  
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2014-07-08
  
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2014-07-08
  
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2013-12-08
  
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2013-10-08
  
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2013-06-03
  
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2013-04-05
  
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2013-03-11
  
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2013-02-06
  
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2013-01-11
  
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2013-01-10
  
2012-12-11
  
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2012-07-05
  
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2012-06-06
  
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2012-05-09
  
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2012-03-13
  
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2012-01-12
  
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2012-01-12
  
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2011-09-07
  
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2011-08-09
  
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2011-04-07
  
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2011-02-08
  
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2011-01-04
  
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2011-01-04
  
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2010-12-09
  
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2010-11-10
  
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2010-09-08
  
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2010-08-09
  
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2010-05-05
  
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2010-04-01
  
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2010-03-08
  
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2010-01-27
  
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2010-01-05
  
2009-12-04
  
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2009-11-04
  
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2009-11-03
  
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2009-10-26
  
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2009-06-01
  
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2009-05-05
  
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2009-04-06
  
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2009-04-03
  
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2009-03-09
  
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2009-01-14
  
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2008-12-10
  
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2008-12-10
  
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2008-10-21
  
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2008-10-21
  
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2008-10-21
  
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2008-09-19
  
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2008-08-25
  
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2008-04-21
  
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2008-01-08
  
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2007-12-11
  
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2007-11-14
  
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2007-11-14
  
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2007-06-18
  
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2007-06-12
  
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2007-05-07
  
2007-03-26
  
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2006-04-22
  
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2005-05-23
  
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2005-03-24
  
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2005-03-24
  
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2005-03-23
  
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2005-03-23
  
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