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High Throughput Screening NEWS
2019-12-03 |
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Code: E12031901 |
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BMG Labtech
VEGF was fluorescently labeled at a single site. This ligand was used with HEK293 expressing VEGF-receptor 2 (VEGFR2) fused to NanoLuc®. Interaction between ligand and receptor leads to BRET between luciferase and fluorophore. Both signals were acquired simultaneously with the PHERAstar®. This way, pKi of a VEGF-inhibitor and time-course of inhibition were measured.
Receptor tyrosine kinases (RTK) such as VEGF are transmembrane receptors that translate stimulation by growth factors to cell death or cell growth. Aberrant RTK-signaling is implicated in cancer, making it a therapeutic target.
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2019-06-27 |
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Code: E06271901 |
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BMG Labtech
YEATS domains are epigenetic regulators and readers of histone post-translational modifications. They bind to lysine when the ε-carbon is acylated. The YEATS-containing ENL is a major driver of several types of acute leukaemia and a rational drug target.
An AlphaScreen-based peptide binding assay was developed that reports on the interaction of modified histone 3 with the YEATS domains. Inhibitor screening was performed on a PHERAstar® and uncovered a potent small molecule inhibitor interfering with the YEATS domains of ENL and AF9.
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2019-03-26 |
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Code: E03271901 |
2018-08-21 |
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Code: E08221803 |
2017-10-10 |
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Code: E10111704 |
2014-03-11 |
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Code: E03121403 |
2014-01-20 |
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Code: E01201401 |
2013-08-14 |
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Code: E08131301 |
2012-03-13 |
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Code: E0031211 |
2010-07-21 |
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Code: E07201001 |
2010-04-19 |
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Code: E04190102 |
2010-04-01 |
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Code: E04011001 |
2010-03-08 |
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Code: E03071001 |
2010-02-04 |
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Code: E02041001 |
2010-01-27 |
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Code: E01271001 |
2009-11-20 |
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Code: E11230902 |
2009-10-26 |
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Code: E10280902 |
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